What It Is
KI-02 is a targeted corrective serum designed to regulate inflammatory signalling within the skin’s sebaceous and immune microenvironment.
The formula is built around a specialised 10-hydroxydecanoic acid bioactive system inspired by fatty acids found in royal jelly. These molecules influence inflammatory signalling pathways and help rebalance microbial conditions associated with acne, congestion, and reactive skin states.
Within the SKNtelligence architecture this product operates inside the Knowledge Index layer, delivering focused biological intervention for inflammatory skin imbalance.
Why It Matters
Many common skin concerns originate from dysregulated inflammatory signalling.
This includes:
• inflammatory acne
• redness and reactivity
• sebaceous imbalance
• congestion and blackheads
• rosacea-prone instability
Conventional acne treatments often rely on exfoliating acids or aggressive antimicrobials, which can disrupt the skin barrier and worsen sensitivity.
KI-02 instead focuses on upstream inflammatory modulation, helping restore stability to the skin’s immune and sebaceous environment.
The Science
The formula uses a 10-HDA fatty acid system delivered through the AzePore™ bioactive complex.
Inflammatory Signalling Modulation
Research associated with 10-hydroxydecanoic acid demonstrates suppression of IRF-1 signalling, which reduces activation of interferon-stimulated response elements and lowers expression of inducible nitric oxide synthase.
Reduced nitric oxide signalling helps decrease inflammatory skin responses.
Sebaceous Microenvironment Control
The fatty acid system can influence sebocyte behaviour and may contribute to improved regulation of sebum production and sebaceous stability.
Microbial Environment Modulation
Supplier testing demonstrates inhibitory pressure against organisms associated with sebaceous imbalance, including several Malassezia species involved in inflammatory acne environments.
Together these mechanisms help restore stability to inflammatory and congested skin conditions.
Visible Benefits
Regular use may support:
• reduction in inflammatory acne activity
• reduced redness and reactivity
• improvement in congestion and blackheads
• improved pore appearance
• reduced sebaceous shine
• improved skin texture
Over time the skin appears calmer, clearer, and more stable.
How To Use
KI-02 is typically used in the evening routine.
Within the SKNtelligence system it is applied after Signal Matrix products and before moisturising or barrier-support products.
Routine order:
Cleanse → Signal Matrix → KI-02 → Nourishment Substrate
Use 1–2 drops and distribute evenly across the skin.
Protocol Integration
KI-02 appears in several SKNtelligence corrective protocols.
Acne Control Protocol
AM
SM-01 Cellular Activator
KI-Cu-02 Sebum Modulation
NS-01 Stabilising Substrate
PM
SM-02 Signal Amplification
KI-02 Inflammatory Modulation
NS-02 Ceramide Lipid
Congestion Control Protocol
AM
SM-01
KI-Cu-02
NS-01
PM
SM-02
KI-02
NS-02
Reactive Skin Protocol
AM
SM-01
KI-02
NS-01
PM
SM-02
KI-02
NS-02
These protocols allow inflammatory regulation without relying on exfoliating acids or aggressive antimicrobial systems.
Ingredient List
INCI
Aqua, Butylene Glycol, 10-Hydroxydecanoic Acid, 1,10-Decanediol, Sebacic Acid, Glycerin, Hydroxyethylcellulose, Phenoxyethanol, Ethylhexylglycerin
Documentation
Download the full SKNtelligence documentation set:
• Consumer Product Brochure
• Technical Ingredient Dossier
• Professional Protocol Guide
