What It Does
SM-01 delivers a powerful biological signal to the skin.
Built around transdermal Epidermal Growth Factor (T-EGF), this biotech signalling cream activates the cellular pathways responsible for skin repair, renewal, and regeneration.
Growth factors are naturally occurring signalling molecules used by the body to coordinate tissue repair. As we age, the availability of these signals declines.
SM-01 restores this signalling environment, helping skin behave more like younger skin.
Within the SKNtelligence system it functions as the Signal layer, preparing the skin for intervention products applied afterwards.
The Science
Epidermal Growth Factor (EGF) binds to epidermal growth factor receptors (EGFR) on skin cells.
This activates several regenerative signalling pathways including:
PI3K/AKT pathway
ERK/MAPK pathway
These cascades stimulate:
keratinocyte proliferation
fibroblast activity
extracellular matrix synthesis
This leads to improved collagen production, elastin formation and tissue repair.
SM-01 uses transdermal peptide delivery technology to improve penetration of the growth factor through the skin barrier.
Visible Skin Benefits
Regular use may support:
improved skin regeneration
smoother skin texture
improved elasticity
reduction in visible wrinkles
faster skin recovery after stress
Over time skin appears firmer, smoother and more resilient.
How To Use
Apply a small amount to clean skin.
Within the SKNtelligence system the layering order is:
Signal Matrix → Knowledge Index → Nourishment Substrate
SM-01 should be applied first, immediately after cleansing.
It activates the skin’s biological repair pathways before targeted actives are introduced.
Protocol Integration
SM-01 appears in several SKNtelligence protocols.
The Regeneration Protocol
AM
SM-01 Cellular Activator
KI-Cu-01 Regeneration Amplifier
NS-01 Stabilising Substrate
PM
SM-02 Signal Amplification
KI-EX-01 Epigenetic Repair
NS-02 Ceramide Lipid
The Pigment Reset Protocol
AM
SM-01
KI-TA-01 Pigment Interruption
NS-01
PM
SM-02
KI-EX-01
NS-02
The Recovery Protocol
AM
SM-01
KI-Cu-01
NS-01
PM
SM-02
KI-EX-01
NS-02
These protocols leverage SM-01 to activate the skin’s biological signalling environment before intervention products are applied.
Full Ingredient List
INCI
Aqua, Helianthus Annuus Seed Oil, Caprylic/Capric Triglyceride, Glyceryl Stearate SE, Cetearyl Alcohol, Glycerin, Phenoxyethanol, Sodium Stearoyl Glutamate, Xanthan Gum, Ethylhexylglycerin, sr-(Hexapeptide-40 Oligopeptide-232 sh-Oligopeptide-1).
Scientific Documentation
Download the supporting SKNtelligence documents:
Consumer Product Brochure
Technical Ingredient Dossier
Professional Protocol Guide
